Study on Combination Therapies with Adagrasib for Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation
Sponsor: Mirati Therapeutics Inc.
ClinicalTrials ID:NCT05609578
This clinical trial is testing a new treatment approach using adagrasib combined with pembrolizumab and chemotherapy for patients with advanced non-small cell lung cancer (NSCLC) that has a specific genetic mutation called KRAS G12C.
Patient Parameters
| Parameter | Options |
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Program Overview
The purpose of this study is to evaluate how well a combination of treatments, including adagrasib, pembrolizumab, and chemotherapy, works for patients with advanced non-small cell lung cancer (NSCLC) that has a KRAS G12C mutation. The study focuses on patients whose cancer has a certain level of a protein called TPS, which is involved in the cancer's growth.
Eligibility Criteria
Exclusion Criteria
- Have received any previous treatment targeting the KRAS G12C mutation.
- For certain groups, have had previous treatments for advanced NSCLC, including chemotherapy, immune therapy, or a combination of both, unless it was given more than a year ago in a different setting.
- For specific groups, have received maintenance therapy like pembrolizumab or pemetrexed after initial chemotherapy.
- Have had radiation to the lung greater than 30 Gy within six months before starting the study treatment.
- Have active cancer that has spread to the brain.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Local Institution - Unk025 | 99508 | Anchorage | Alaska |
| Local Institution - 017-591 | 85304 | Glendale | Arizona |
| Local Institution - 017-821 | 85004 | Phoenix | Arizona |
| Local Institution - Unk047 | 92805 | Anaheim | California |
| Local Institution - 017-936C | 92708 | Fountain Valley | California |
| MemorialCare - Orange Coast Medical Center | 92708 | Fountain Valley | California |
| Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton | 92835 | Fullerton | California |
| Local Institution - Unk004 | 92354 | Loma Linda | California |
| Local Institution - 017-961 | 90095 | Los Angeles | California |
| UCSF Helen Diller Family Comprehensive Cancer Center | 94158 | San Francisco | California |
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