Study on Habitat Escalated Adaptive Therapy (HEAT) with Pre-Surgery Radiation for Soft Tissue Sarcoma

Inclusion Criteria

• Must provide signed and dated consent to participate in the study.
• Willingness to follow all study procedures and be available for the entire study duration.
• Women who can become pregnant must use highly effective birth control for at least one month before the study and continue for 52 weeks after radiation treatment.
• Men who can father children must use condoms or other effective birth control methods with their partners for 52 weeks after radiation treatment.
• Agree to follow lifestyle guidelines as outlined in the study protocol.
• Must have a confirmed diagnosis of high-grade (grade 2 or 3) Soft Tissue Sarcoma (STS) located deep in the trunk or limbs.
• The primary tumor site must be considered removable by surgery before starting the trial.
• Cancer staging must be T1-4 N0 M0, meaning no distant spread of the cancer.
• Must have measurable disease at the primary tumor site, confirmed by clinical or imaging evidence.
• Must have an MRI scan within 4 weeks before starting radiation therapy.
• Must have an ECOG Performance Status score between 0 and 3, indicating varying levels of activity.
• Must be considered a candidate for surgery.
• Must agree to have blood and plasma samples preserved for future research.

Exclusion Criteria

• Cannot undergo an MRI scan.
• Positive pregnancy test.
• Complete removal of the primary tumor, including any unplanned removal.
• Superficial sarcoma located mainly in the skin or just below the skin.
• Previous radiation treatment to the same area that would overlap with the study's radiation fields.
• Any medical condition or social situation that, in the opinion of the study leader, would prevent completion of the trial.