Study on the Effectiveness and Safety of Various Immunotherapy Combinations for Advanced Liver Cancers (Morpheus-Liver)

Inclusion Criteria

Stage 1

• Must be in good overall health with a performance status score of 0 or 1.
• Have advanced liver cancer that cannot be removed by surgery.
• Have not received any previous systemic treatment for liver cancer.
• Have a life expectancy of at least 3 months.
• Provide a tumor sample for testing.

Stage 1 and Stage 2

• Have measurable disease based on specific criteria.
• Have good blood and organ function.
• Have documented hepatitis status.
• Test negative for HIV.
• Agree to use contraception if of childbearing potential.

Stage 2

• Must be in good overall health with a performance status score of 0, 1, or 2.
• Able to start Stage 2 treatment within 3 months if needed.
• Provide a tumor sample from a biopsy if possible.

NKT2152-Containing Arm:

• Have specific liver function test results within acceptable limits.

Exclusion Criteria

Stage 1

• Have had certain previous treatments or therapies.
• Have untreated or high-risk esophageal or gastric varices.
• Have unresolved side effects from previous cancer treatments.
• Have uncontrolled high blood pressure or significant vascular disease.
• Have had recent bleeding or certain medical conditions.
• Have had recent major surgery or procedures.
• Have certain other medical conditions or treatments.

Stage 1 and 2

• Have specific types of liver cancer or other medical conditions.
• Have uncontrolled pain or fluid buildup.
• Have active or history of autoimmune disease.
• Have active infections or significant heart disease.
• Have had recent major surgery or other cancer treatments.
• Have had a recent severe infection or are taking certain medications.
• Have had a recent live vaccine or severe allergic reactions.
• Have unresolved side effects from previous immunotherapy.