Study on mRNA-4359 Alone and with Immune Checkpoint Blockade for Advanced Solid Tumors

Inclusion Criteria

• Have advanced or metastatic cancer, such as melanoma, lung cancer, bladder cancer, or others, that can be measured by scans.
• Have tried at least one standard treatment for advanced cancer, but it didn't work or you couldn't tolerate it.
• Have a tumor that can be biopsied and another that can be monitored for response.
• For certain lung cancer patients, have tried or been offered targeted therapies if you have specific genetic mutations.
• Be in good general health with a performance status of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Have adequate blood and organ function based on specific tests.

Exclusion Criteria

• Have active tumors or cancer spread in the brain or central nervous system.
• Have received other cancer treatments or investigational drugs recently.
• Need additional immune-suppressing medications or have unresolved side effects from previous treatments.
• Plan to receive or have recently received a live vaccine.
• Have unresolved side effects from previous cancer treatments, except for hair loss or skin changes.
• Are pregnant, breastfeeding, or able to become pregnant and not using effective birth control.
• Are sexually active and not using condoms or planning to donate sperm during and after the study.
• Have any serious or unstable medical conditions that could affect your safety or ability to participate in the study.
• Are enrolled in another clinical study, unless it's observational and non-interventional.