Phase II Study for Personalized Treatment of p16+ Oropharyngeal Cancer at University of Michigan (CuSToMIze)

Inclusion Criteria

• Diagnosed with squamous cell carcinoma of the oropharynx (such as tonsil or base of tongue) that is p16 positive or HPV positive.
• Cancer is at Stage I-II according to the AJCC 8th edition.
• No cancer spread to distant parts of the body.
• Must have a PET scan showing active cancer.
• Must be 18 years or older.
• Must be able to undergo PET/CT imaging.
• For surgical candidates, tumors must be removable through the mouth.
• Must have adequate blood cell counts and kidney function.
• Women and men must agree to use effective birth control during the study.
• Must provide informed consent to participate.

Exclusion Criteria

• Cancer at Stage 3 or 4, or with certain advanced features.
• Previous invasive cancer unless disease-free for at least 3 years.
• Previous treatment for the current cancer.
• Previous radiation in the same area that would overlap with study treatment.
• Severe health conditions like recent heart attack or severe infections.
• AIDS or severe liver problems.
• Pregnant or not willing to use birth control.
• Poorly controlled diabetes for certain participants.
• Enrolled in another active treatment clinical trial for the same cancer.