Study on Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation for Early Breast Cancer

Inclusion Criteria

• Must be able to undergo an MRI scan as part of the treatment planning.
• The area where the tumor was removed must be clearly visible on scans.
• Women of childbearing age must have a negative pregnancy test.
• Must agree to participate and sign a consent form.
• Can have a history of other cancers if they have been cancer-free for 5 years or more, or if they had certain types of cancer treated within the last 5 years.

For participants with Invasive Carcinoma:

• Suitable if:
  • Age 50 or older
  • Tumor margins are clear by at least 2 mm
  • Tumor stage Tis or T1
• Cautionary if:
  • Age 40-49 with clear margins and tumor stage Tis or T1
  • Age 50 or older with certain factors like tumor size 2.1-3.0 cm, close margins, or specific tumor characteristics

For participants with DCIS:

• Suitable if:
  • Detected by screening
  • Low to intermediate grade
  • Size 2.5 cm or smaller
  • Margins clear by 3 mm or more
• Cautionary if:
  • Pure DCIS 3 cm or smaller if not fully meeting suitable criteria

Exclusion Criteria

• Men cannot participate.
• Positive for BRCA1/2 mutation.
• Under 40 years old.
• Positive tumor margins after surgery.
• Suspicious lymph nodes unless confirmed negative for cancer.
• Suspicious breast findings unless confirmed benign.
• Non-epithelial breast cancers.
• Multiple cancer sites in the breast.
• Pure DCIS larger than 3 cm.
• Extensive intraductal component larger than 30 mm.
• Paget's disease of the nipple.
• History of previous breast cancer or certain other breast conditions.
• Cannot assess or have positive surgical margins.
• Using certain hormonal therapies.
• Have breast implants.
• Previous breast or chest radiation.
• Certain collagen vascular diseases.
• Pregnant or breastfeeding. Women must use non-hormonal contraception.
• Conditions that prevent meeting study requirements.