Study on the Safety of Pentoxifylline and Vitamin E with Stereotactic Ablative Radiotherapy (SABR) for Non-small Cell Lung Cancer

Inclusion Criteria

• Must be 18 years or older.
• Must have a good overall health status, able to carry out normal activities or light work.
• Must have a confirmed diagnosis of a previous lung cancer that was treated with radiation, with or without chemotherapy.
• Must have a new or returning lung cancer in the same area as the previous cancer or nearby lymph nodes.
• Must have a CT scan of the chest with contrast and a whole-body PET scan within 8 weeks before joining the study.
• Must have a lung function test, including a diffusion capacity test, within 8 weeks before joining the study.
• Women who can become pregnant must have a negative pregnancy test within 2 weeks before joining the study.
• Women and men who are sexually active must agree to use effective birth control.
• Must agree to participate and sign a consent form before starting the study.

Exclusion Criteria

• Cannot have had previous radiation therapy to the chest.
• Cannot have very low lung function, specifically FEV1 or DLCO less than 20% of what is predicted.
• Cannot be pregnant or breastfeeding.
• Cannot have had chemotherapy within 4 weeks before starting SABR.
• Cannot plan to have chemotherapy at the same time as the radiation therapy.