Phase II Study on the Effects of Heated Chemotherapy During Laparoscopic Surgery for Advanced Stomach Cancer

Inclusion Criteria

• Diagnosed with advanced stomach cancer that has spread to the abdomen, and have completed 2 to 4 months of prior chemotherapy.
• Aged 18 years or older.
• In good general health with a performance status score of 2 or less, meaning able to carry out light work or more.
• Have adequate blood cell counts and organ function, including:
  • White blood cells of at least 3,000/mcL.
  • Neutrophil count of at least 1,500/mcL.
  • Platelet count of at least 100,000/mcL.
  • Normal liver and kidney function as indicated by specific blood tests.
• HIV-positive patients can participate if they are on effective treatment with an undetectable viral load.
• Patients with hepatitis B or C can participate if their viral load is undetectable or they have been cured.
• No other cancers that could interfere with the study.
• Heart function must be stable, with a classification of 2B or better.
• Expected to live for more than 3 months.
• Women and men must agree to use effective birth control during the study and for a period after the study ends.
• Must be able to understand and sign a consent form.

Exclusion Criteria

• Have another untreated cancer, except for certain skin cancers, within the last five years.
• Cancer has spread to organs like the liver, lungs, bones, or brain.
• Have not fully recovered from side effects of previous cancer treatments, except for hair loss.
• Currently taking other experimental drugs.
• Have allergies to similar drugs used in the study.
• Have uncontrolled illnesses or psychiatric conditions that could affect participation.
• Pregnant or breastfeeding women cannot participate due to potential risks to the baby.