Study on New Immunotherapy Combinations for Untreated Advanced or Metastatic Non-Small-Cell Lung Cancer

Inclusion Criteria

• Diagnosed with advanced non-small-cell lung cancer (NSCLC) that cannot be removed by surgery or treated with radiation alone.
• Have not received any previous treatment for advanced or metastatic NSCLC.
• Able to provide a recent tumor sample for testing.
• Tumors must have high levels of PD-L1 (a protein that helps cancer cells hide from the immune system).
• Have measurable cancer that can be tracked using standard criteria.
• Be in good overall health with a performance status score of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Have adequate organ function as determined by specific medical tests.
• Female participants who can become pregnant must agree to use effective birth control.

Exclusion Criteria

• Have specific genetic mutations in the cancer that can be treated with approved therapies.
• Have had major surgery within the last 4 weeks or significant lung radiation within the last 6 months.
• Have received any previous treatment with immune checkpoint inhibitors.
• Have never smoked or smoked fewer than 100 cigarettes in their lifetime.
• Have had another invasive cancer within the last 5 years, with some exceptions.
• Have untreated or worsening brain cancer or cancer in the membranes around the brain.
• Have an autoimmune disease that required treatment in the last 2 years.
• Are taking medications that suppress the immune system.
• Have received a live vaccine within 30 days before starting the study.
• Have a history of lung diseases like pulmonary fibrosis or pneumonitis.
• Have had heart problems in the last 6 months.
• Have unstable liver or bile duct disease.
• Have had a severe infection in the last 4 weeks.
• Test positive for tuberculosis, HIV, hepatitis B, or hepatitis C.
• Have advanced cancer that is causing life-threatening complications.
• Are currently in another clinical trial or have been in one within the last 4 weeks.
• Have had a tissue or organ transplant.