Cord Blood Transplant for Children and Young Adults with Blood Cancers and Non-Cancerous Disorders

Inclusion Criteria

• Children and young adults aged 21 or younger without a suitable donor for a traditional transplant.
• Diagnosed with certain types of blood cancers like acute myelogenous leukemia (AML) or acute lymphoblastic leukemia (ALL) at high risk of returning or not responding to treatment.
• Diagnosed with other blood disorders like myelodysplastic syndrome (MDS) or myeloproliferative disorders (MPD) that are life-threatening.
• Diagnosed with high-risk non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL) that is not in remission.
• Diagnosed with certain inherited metabolic disorders early in the disease, such as Hurler Syndrome or Metachromatic Leukodystrophy.
• Diagnosed with non-cancerous blood disorders like hemoglobinopathies or bone marrow failure syndromes.
• Must have good organ function and be in relatively good health, with specific blood and organ function levels.
• Must meet specific criteria for cord blood transplant, including matching and cell count requirements.

Exclusion Criteria

• Poor overall health or organ function.
• Advanced metabolic disease.
• Active leukemia in the central nervous system.
• Progression of indolent NHL or Hodgkin lymphoma after recent treatment.
• Diagnosed with myelofibrosis or other cancers with significant bone marrow issues.
• Recent autologous stem cell transplant within the last 6 months.
• Previous allogeneic stem cell transplant.
• Active and uncontrolled infections at the time of transplant.
• HIV infection or positive for HTLV-1.
• Pregnant or breastfeeding.
• Unable to provide informed consent or follow the treatment plan.