Study on CTX-712 for Treating Relapsed or Hard-to-Treat Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

Inclusion Criteria

• Must be 18 years or older.
• Have a diagnosis of acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (HR-MDS), or certain related conditions.
• Have received 1 to 4 previous treatments for these conditions.
• Have good organ function based on specific blood test results.
• Have a performance status score of 2 or less, indicating the ability to carry out daily activities with some limitations.
• Women who can become pregnant must have a negative pregnancy test before starting the study and agree to use effective birth control during the study and for 4 months after.
• Men with partners who can become pregnant must agree to use effective birth control or abstain from sex during the study and for 4 months after.

Exclusion Criteria

• Have a diagnosis of acute promyelocytic leukemia.
• Have a relapse that is only outside the bone marrow (for Phase 2 only).
• Have active leukemia in the central nervous system.
• Have a history of other cancers.
• Have certain heart or lung conditions, such as recent heart attack, severe heart failure, or serious lung disease.
• Are pregnant or breastfeeding.
• Have had major surgery within 4 weeks before starting the study.
• Have had an organ transplant (except cornea) or a stem cell transplant within 6 months.
• Have had certain types of cell therapy.
• Have an active, uncontrolled infection, including hepatitis B or C, or HIV.
• Have any conditions that would make it difficult to follow the study procedures.