Study on PyL Imaging for Detecting High Risk and Recurrent Prostate Cancer

Sponsor: Hoag Memorial Hospital Presbyterian

Sponsor score: 0
Inactive

ClinicalTrials ID:NCT04700332

Provider View

This clinical trial is testing a new imaging method called PyL PET/CT to see if it can better detect prostate cancer that has spread, compared to standard imaging methods. The study focuses on patients with high risk prostate cancer or those whose cancer has returned after treatment.

Patient Parameters

Program Overview

The study aims to evaluate if PyL PET/CT, a new imaging technique, can more accurately identify significant cancer spread in patients with prostate cancer. This method targets a specific marker on prostate cancer cells, potentially offering better detection than current standard imaging methods like CT scans and bone scans.

Description

This phase II clinical trial is designed to assess the effectiveness of PyL PET/CT in detecting prostate cancer in two groups of patients:

  1. Patients with high risk prostate cancer who are planning to undergo surgery or radiation therapy.
  2. Patients whose prostate cancer has returned, as indicated by rising PSA levels, but who show no signs of cancer spread on standard imaging tests.

In both groups, the PyL PET/CT scan will be performed and analyzed by a specialist in advanced imaging techniques. If the scan reveals areas that look suspicious for cancer, these areas may be biopsied to confirm if cancer is present. The biopsy results will help determine the accuracy of the PyL PET/CT scan in identifying cancer.

Eligibility Criteria

Inclusion Criteria

  • Men aged 18 or older.
  • Diagnosed with prostate cancer.
  • Belong to one of the following groups:
    • High risk prostate cancer with plans for surgery or radiation.
    • Prostate cancer that has returned, shown by increased PSA levels, but no visible spread on standard imaging tests within the last 3 months.

Exclusion Criteria

  • Any condition that might affect the patient's safety or the study's results, as judged by the study doctor.
  • Patients who cannot have a PET/CT scan due to weight limits (over 450 pounds).
  • Changes in treatment since the last standard imaging tests.

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