Study on Lowering Radiation Dose After Surgery for Soft Tissue Sarcoma in Arms and Legs

Sponsor: Memorial Sloan Kettering Cancer Center

Sponsor score: 60
Inactive

ClinicalTrials ID:NCT04288375

Provider View

This clinical trial is exploring whether reducing the amount of radiation and focusing on a smaller area after surgery is as effective as the standard treatment for controlling soft tissue sarcoma in the arms and legs. The study also aims to see if this approach results in fewer and less severe long-term side effects.

Patient Parameters

Program Overview

The purpose of this study is to determine if a lower dose of radiation therapy, targeting a smaller area, is as effective as the standard dose in controlling soft tissue sarcoma after surgery. Researchers also want to find out if this new approach leads to fewer and less severe long-term side effects compared to the standard treatment.

Eligibility Criteria

Inclusion Criteria

  • Diagnosed with primary soft tissue sarcoma in the arms or legs, confirmed by a specific medical review.
  • Age 18 years or older.
  • Have had surgery to remove the tumor with clear margins, confirmed by a specific medical review.
  • Able to start radiation therapy within 3 months after surgery.
    • If receiving additional chemotherapy, radiation must start within 3 months after chemotherapy.
  • Female patients who can become pregnant must have a negative pregnancy test before starting radiation.
  • Sexually active patients who can become pregnant must agree to use effective birth control.
  • Chemotherapy use is not determined by this trial and can be decided by the medical team based on individual needs.

Exclusion Criteria

  • Have positive margins after tumor removal surgery.
  • Diagnosed with a specific type of sarcoma with unclear borders on pre-surgery MRI.
  • Have multiple tumor sites in the arms or legs.
  • Have had previous radiation therapy near the tumor area.
  • Have another invasive cancer that requires active treatment at the time of joining the study.
  • Have any medical or psychiatric condition that makes participation in the study inappropriate, as judged by the investigator.

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