Study on Induction Chemo-Nivo for Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria

• Have Stage IIIA-IIIC non-small cell lung cancer that cannot be removed by surgery and has not been treated before.
• PD-L1 levels can be between 0-100%.
• Do not have specific genetic changes in EGFR, ALK, or ROS1 genes, or these changes are unknown.
• Be in good overall health with an ECOG performance status of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Have good organ and bone marrow function.
• Have enough lung function to handle potential lung surgery.
• If HIV-positive, be on effective treatment with an undetectable viral load in the last 6 months.
• If you have chronic hepatitis B, the virus must be undetectable with treatment.
• If you had hepatitis C, you must be cured or have an undetectable viral load if still on treatment.
• Have no other cancers that would interfere with this study.
• Have a heart function assessment of class 2B or better.
• Be able to understand and sign a consent form.

Exclusion Criteria

• Have participated in another study with an experimental drug or device within the last 2 weeks.
• Have had any previous radiation therapy to the lungs.
• Have had any previous treatment for non-small cell lung cancer.
• Have used any drugs targeting immune checkpoints or T-cell pathways.
• Have had severe allergic reactions to monoclonal antibodies or study drug components.
• Have primary tumors in the esophagus or Pancoast tumors.
• Have tumors that cannot be surgically removed.
• Have a history of allergic reactions to drugs similar to Nivolumab.
• Have an active or past autoimmune disease or conditions requiring steroids or immunosuppressive drugs.
• Need ongoing systemic steroids greater than 10mg of prednisone.
• Have had other cancers in the past.
• Have a history of interstitial lung disease.
• Require continuous oxygen support.
• Have received live vaccines within 4 weeks before starting the study.
• Have an active infection needing treatment.
• Have uncontrolled illnesses or psychiatric conditions that affect study participation.
• Are pregnant or breastfeeding.