Study on KB-0742 for Patients with Relapsed or Hard-to-Treat Solid Tumors or Non-Hodgkin Lymphoma

Inclusion Criteria

• Adults aged 18 and older, or teens aged 12 and older weighing at least 40 kg, with certain types of tumors.
• Willing to provide consent to participate.
• Part 1: Patients with any relapsed or refractory solid tumor or specific types of tumors like small cell lung cancer, ovarian cancer, or certain lymphomas.
• Part 2: Patients with confirmed solid tumors who have no other treatment options.
• Must provide a tumor sample for testing.
• Good overall health with a performance status of 0 or 1.
• Must have measurable disease.
• Adequate bone marrow and organ function.
• Must have recovered from previous treatment side effects.
• Agree to use effective birth control during the study and for 3 months after.

Exclusion Criteria

• Recent use of other cancer treatments within 4 weeks.
• Recent surgery or radiation therapy.
• History of organ transplant within 6 months.
• Active cancer in the brain or spinal cord unless stable for 3 months.
• Recent stroke or brain bleeding.
• History of seizures or taking seizure medications.
• Active infections needing treatment.
• Active COVID-19 infection.
• Significant heart disease or uncontrolled high blood pressure.
• Prolonged QT interval on an ECG.
• Active HIV, hepatitis B, or hepatitis C infection.
• Other uncontrolled medical conditions.