Comparing Gadolinium Contrast-enhanced Abbreviated MRI and Standard Ultrasound for Liver Cancer Screening in Patients with Cirrhosis

Sponsor: University of California, San Diego

Sponsor score: 40
Inactive

ClinicalTrials ID:NCT04288323

Provider View

This study is evaluating whether a new type of MRI scan, called Abbreviated MRI (AMRI), is more effective than the standard ultrasound in detecting liver cancer in patients with cirrhosis.

Patient Parameters

Program Overview

The study aims to find out if a new, quicker MRI scan using gadolinium contrast, called Abbreviated MRI (AMRI), is better than the usual ultrasound for screening liver cancer in people with liver cirrhosis. AMRI is designed to be faster, more comfortable, and potentially as affordable as an ultrasound, without the radiation exposure of a CT scan. This research will help determine if AMRI can be a reliable and cost-effective method for early detection of liver cancer in high-risk patients.

Description

Currently, ultrasounds are used to monitor liver cancer, but they have some limitations. Doctors sometimes use CT or MRI scans, but these can be costly and take a long time. This study introduces a new type of MRI scan called Abbreviated MRI (AMRI), which is quick, taking less than ten minutes, and works well for patients with liver cirrhosis or obesity. Unlike CT scans, AMRI does not use radiation, and it is faster than traditional MRI scans. The study will compare how well AMRI and ultrasound detect early-stage liver cancer in adults with cirrhosis. The goal is to see if AMRI can be a new, fast, accurate, and affordable way to screen for liver cancer in people at high risk.

Eligibility Criteria

Inclusion Criteria

  • Adults of any gender and ethnic background with liver cirrhosis.
  • Must be fully informed about the study and have signed consent forms.
  • Willing to complete all required study procedures, including screenings, evaluations, and both AMRI and ultrasound exams.
  • Open to participating in optional surveys and allowing the study team to review their clinical data, including other radiology reports and images.

Exclusion Criteria

  • Under 18 years old.
  • History of liver cancer.
  • Cannot have an MRI for any reason.
  • Pregnant or trying to become pregnant.
  • Positive pregnancy test for women who can have children.
  • Nursing mothers.
  • Allergic to gadolinium.
  • Does not meet specific guidelines for receiving the contrast agent Eovist.
  • Had a liver screening exam at UCSD within the last 90 days.

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