Study on LBL-007 and Tislelizumab with Bevacizumab and Fluoropyrimidine for Advanced Colorectal Cancer
Sponsor: BeiGene
ClinicalTrials ID:NCT05609370
This clinical trial is testing a new combination of drugs, including LBL-007 and Tislelizumab, with standard treatments bevacizumab and fluoropyrimidine, to see if they are safe and effective for patients with advanced colorectal cancer that cannot be surgically removed.
Patient Parameters
| Parameter | Options |
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Program Overview
The purpose of this study is to evaluate the safety and effectiveness of a new drug combination, LBL-007 and Tislelizumab, when used with bevacizumab and fluoropyrimidine in patients with colorectal cancer that has spread or cannot be removed by surgery. This study is in Phase 1b/2, which means it is testing both the safety and how well the treatment works.
Eligibility Criteria
Inclusion Criteria
- Have colorectal cancer that has spread or cannot be removed by surgery, confirmed by lab tests.
- Have not received any previous treatments for colorectal cancer that has spread, except for initial treatment.
- Have completed initial treatment with stable disease or better results.
- Have at least one tumor that can be measured by scans.
Exclusion Criteria
- Cancer has become operable during or after initial treatment.
- Initial treatment started less than 6 months after finishing any previous chemotherapy or radiation.
- Have been treated with anti-EGFR antibody during initial treatment.
- Have had previous treatments targeting T-cell pathways.
- Have a specific BRAF gene mutation (BRAF V600E).
- Have high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR) confirmed by specific tests.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Alaska Oncologyand Hematology, Llc | 99508 | Anchorage | Alaska |
| Banner Md Anderson Cancer Center | 85234 | Gilbert | Arizona |
| Toi Clinical Research | 90703 | Cerritos | California |
| Usc Norris Comprehensive Cancer Center (Nccc) | 90033 | Los Angeles | California |
| UCLA | 90095 | Los Angeles | California |
| Hoag Memorial Presbyterian | 92663 | Newport | California |
| Baptist Md Anderson Cancer Center | 32207 | Jacksonville | Florida |
| Fort Wayne Medical Oncology and Hematology | 46804 | Fort Wayne | Indiana |
| Baptist Health Lexington | 40503 | Lexington | Kentucky |
| University of Kentucky Markey Cancer Center | 40536 | Lexington | Kentucky |
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