Study on Using Targeted Radiation Therapy for High-Risk Spine Cancer Spread
Sponsor: Stony Brook University
ClinicalTrials ID:NCT06165419
This clinical trial is exploring whether patients with cancer that has spread aggressively to the spine can be effectively treated with a precise form of radiation therapy, potentially avoiding the need for major spine surgery.
Patient Parameters
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Program Overview
The purpose of this study is to determine if stereotactic body radiation therapy (SBRT), a highly targeted form of radiation treatment, can be used alone to treat patients whose cancer has spread to the spine in a high-risk manner. The goal is to see if this approach can control the cancer effectively without the need for extensive spine surgery.
Eligibility Criteria
Eligible patients must have:
- Any pathologically proven solid tumor diagnosis not of central nervous system origin with radiographic or pathologic evidence of metastatic disease
- Metastatic spine involvement documented by imaging
- Involvement of maximum 3 contiguous vertebral bodies at the index site
- Intact neurologic function, or only minor neurologic deficits with muscle strength greater or equal to 4 out of 5 with or without steroids
- An evaluation by an radiation oncology and orthopedic spine/neurosurgery attending
- ECOG Performance Status of 0-3
Patients are ineligible if they have:
- An unstable spine defined as a Spinal Instability Neoplastic Score (SINS) greater than 12
- Had previous surgery or radiation to address the target spinal metastases
- Radiosensitive tumors (e.g. small cell lung cancer, lymphoma, multiple myeloma, and germ-cell tumors)
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