Study on Using Bethanechol with Chemotherapy for Pancreatic Cancer

Sponsor: Susan E. Bates

Sponsor score: 0
Inactive

ClinicalTrials ID:NCT05241249

Provider View

This clinical trial is testing whether adding the drug bethanechol to standard chemotherapy can improve surgery outcomes for pancreatic cancer patients. The study also looks at the safety of this combination and explores how it might slow down cancer growth.

Patient Parameters

Program Overview

The main goal of this study is to see if the drug bethanechol, when used with chemotherapy drugs gemcitabine and nab-paclitaxel, can help improve the success of surgery in removing pancreatic cancer. Researchers also want to ensure that this combination is safe and well-tolerated by patients. Additionally, the study will explore how bethanechol might affect cancer growth by stimulating certain nerves in the body.

Description

This study is investigating whether the drug bethanechol can be used alongside chemotherapy drugs gemcitabine and nab-paclitaxel to help prevent pancreatic cancer from returning after surgery. In animal studies, bethanechol has shown potential in slowing down cancer growth and spread. While gemcitabine and nab-paclitaxel are already approved for treating metastatic pancreatic cancer, the use of bethanechol in this study is experimental. The researchers aim to demonstrate that bethanechol is easy for patients to tolerate and that it can slow down the growth of cancer cells. They believe that bethanechol may work by affecting nerve signals within tumors, which could lead to slower cancer growth and better surgical outcomes.

Eligibility Criteria

Inclusion Criteria

  • Diagnosed with Pancreatic Ductal Adenocarcinoma.
  • Planning to receive chemotherapy before surgery.
  • Have tissue samples available for testing specific markers.
  • Able to take oral medications and follow study procedures.

Exclusion Criteria

  • Cancer has spread to other parts of the body.
  • Have a blockage in the digestive system.
  • Have a slow heart rate (below 55 beats per minute) or low blood pressure (below 90 systolic).
  • Taking medications that affect nerve signals, like acetylcholinesterase inhibitors.
  • Have certain medical conditions such as overactive thyroid, heart disease, seizure disorder, or stomach ulcers.

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