Study on DCC-3116 Combined with Other Cancer Treatments for Advanced Cancers

Inclusion Criteria

• Must be 18 years or older.
• For Module B, Part 1: Must have a confirmed diagnosis of gastrointestinal stromal tumor (GIST) with a specific mutation and have tried at least one approved treatment that didn't work or couldn't be tolerated. Must not have taken ripretinib before.
• For Module B, Part 2: Must have GIST with a specific mutation and have tried imatinib without success or couldn't tolerate it, and not have tried other treatments for GIST.
• Must have measurable cancer.
• Must have a life expectancy of more than 3 months and be in good general health (ECOG status 0-1).
• Must have good organ function and bone marrow health based on lab tests.
• Must provide a fresh tumor biopsy and, if available, a previous tumor tissue sample.
• Must agree to provide a biopsy during treatment.

Exclusion Criteria

• Must not have taken certain medications, including some cancer treatments and herbal supplements like St. John's wort, within a specified time before starting the study.
• Must not have taken grapefruit or grapefruit juice within 14 days before starting the study.
• Must have recovered from any significant side effects of previous treatments.
• Must not have severe heart disease or recent heart problems.
• Must not have cancer that has spread to the brain or spinal cord.
• Must not have malabsorption syndrome.
• Must not have bone disease needing treatment within 6 months before the study.
• Must not have had major surgery within 4 weeks before starting the study.
• Must not have active infections like HIV, Hepatitis B, or Hepatitis C.