Study on Azeliragon and Stereotactic Radiation Therapy for Patients with Brain Metastases

Inclusion Criteria

• Diagnosed with cancer within the last 5 years, or have recent confirmation of cancer if diagnosed more than 5 years ago.
• Aged 18 years or older.
• Have a performance status score indicating ability to carry out daily activities with some assistance.
• Have a brain tumor with the largest lesion measuring 2 cm or less.
• Must have stopped taking corticosteroids at least 5 days before starting radiation therapy, unless part of the study treatment.
• Not pregnant or breastfeeding, and agree to use effective birth control during treatment and for 6 months after.
• Eligible if previously treated with stereotactic radiosurgery, as long as there are new brain lesions and at least 2 months have passed since the last treatment.
• Have adequate blood counts and organ function as shown by specific blood tests taken within 14 days before joining the study.

Exclusion Criteria

• Have cancer that has spread to the membranes surrounding the brain and spinal cord.
• Unable to have an MRI scan.
• Taking certain medications that interfere with the study drug.
• Have digestive issues that affect swallowing or absorbing medication.
• Not willing to use effective birth control if of childbearing potential or have a partner who is.
• Participating in another treatment-focused clinical trial or using another experimental drug within 7 days of starting the study drug.
• Considered unsuitable for the trial by the lead researcher.