Study of AZD5305 Alone and with Other Cancer Treatments in Patients with Advanced Solid Tumors

Inclusion Criteria

• Must be 18 years or older.
• Have a confirmed diagnosis of advanced cancer suitable for the study treatment.
• Have a performance status score of 0 to 2, indicating full activity or some restriction in strenuous activities.
• Have a life expectancy of at least 12 weeks.
• Cancer must be progressing at the time of joining the study.
• Must have measurable disease as defined by specific criteria for different parts of the study.
• Must have adequate organ and bone marrow function as per the study protocol.
• For Part B, must provide a tumor sample if available, unless stated otherwise in a specific module.

For Part A:

• May have had one prior treatment with a PARP inhibitor.

For Part B:

• Must not have had prior treatment with a PARP inhibitor.

Exclusion Criteria

• Recent treatment with certain chemotherapy drugs or investigational agents.
• Use of medications or supplements that affect liver enzymes or heart rhythm.
• Use of high-dose steroids.
• Recent major surgery or radiation therapy.
• History of severe blood cell deficiencies.
• Untreated or unstable brain or spinal cord cancer spread.
• Bleeding disorders or recent serious bleeding events.
• Certain heart conditions or recent heart events.
• Blood disorders like myelodysplastic syndrome or acute myeloid leukemia.
• Severe digestive issues that affect drug absorption.
• Allergies to the study drug or its ingredients.
• Other cancers that could interfere with the study.