Study on Using Laser Treatment for Small Papillary Thyroid Cancer

Sponsor: Memorial Sloan Kettering Cancer Center

Sponsor score: 60
Inactive

ClinicalTrials ID:NCT04623801

Provider View

This clinical trial is investigating whether using a laser to treat small papillary thyroid cancer is a safe and effective alternative to surgery.

Patient Parameters

Program Overview

The aim of this study is to find out if using a laser to treat small papillary thyroid cancer (PTMC) is a safe and effective option instead of surgery. This method, called percutaneous laser ablation (PLA), involves using a laser to target and destroy the cancer cells in the thyroid.

Eligibility Criteria

Inclusion Criteria

  • Must be 18 years or older.
  • Have papillary thyroid cancer confirmed by:
    • (a) Specific test results known as Bethesda VI cytology, or
    • (b) Bethesda III, IV, V, or VI cytology along with a specific gene mutation (BRAF V600E), or
    • (c) Bethesda V cytology with high-risk features seen on an ultrasound.
  • The cancer must be 13 mm or smaller in size.
  • Have chosen not to undergo active surveillance (regular monitoring without immediate treatment).
  • The thyroid tumor must be mostly solid, with no more than 25% being fluid-filled.
  • No signs of the cancer spreading beyond the thyroid gland.
  • No signs of cancer spreading to lymph nodes on imaging tests.
  • Normal function of the vocal cords on the opposite side of the thyroid before the laser treatment.

Exclusion Criteria

  • Have a type of thyroid cancer other than papillary thyroid cancer.
  • Have a thyroid tumor that is more than 25% fluid-filled.
  • Have signs of the cancer spreading beyond the thyroid gland.
  • Have signs of cancer spreading to lymph nodes.
  • Are pregnant.

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