* Known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy * Eligible for first-line treatment with IMbrave150 or STRIDE regimens * Any of the following because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown: * Pregnant persons * Nursing persons * Persons of childbearing potential who are unwilling to employ adequate contraception * Any of the following prior therapies: * Surgery =\< 4 weeks prior to registration * Radiotherapy for extended field =\< 4 weeks prior to registration or limited field radiotherapy =\< 2 weeks prior to registration * Systemic anticancer therapy =\< 2 weeks prior to registration * NOTE: Prior immunotherapy is allowed unless patient discontinued due to grade 4 adverse event (AE) * Live vaccine =\< 30 days prior to registration * Prior treatment with FGFR inhibitor * Received strong inhibitors and inducers and sensitive substrates of CYP3A4 =\< 2 weeks prior to registration * Received a drug that has not received regulatory approval for any indication as follows: * =\< 2 weeks prior to registration for nonmyelosuppressive agents or * =\< 4 weeks prior to registration for myelosuppressive agents * History and/or current evidence of any of the following disorders: * Retinal or corneal disorder confirmed by retinal/corneal examination and considered clinically significant in the opinion of the Investigator * Pneumonitis or interstitial lung disease within =\< 3 years prior to registration * Active central nervous system (CNS) metastasis and/or carcinomatous meningitis * NOTE: Patients with previously treated brain metastases that are clinically and radiologically stable (for at least 4 weeks prior to enrollment) are eligible * Corrected QT interval using Fridericia's formula (QTcF) \> 480 msec * NOTE: Patients with an atrioventricular pacemaker or other condition (for example, right bundle branch block) that renders the QT measurement invalid are an exception and the criterion does not apply * Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens * Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm * History or risk of autoimmune disease, including, but not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis. Notes: * Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone are eligible. * Patients with controlled Type 1 diabetes mellitus on a stable insulin regimen are eligible. * Patients with eczema, psoriasis, lichen simplex chronicus of vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions: * Must not have ocular manifestations * Rash must cover less than 10% of body surface area (BSA) * Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, flucinolone 0.01%, desonide 0.05%, aclometasone dipropionate 0.05%) * No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation \[PUVA\], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids) * Known active human immunodeficiency virus (HIV) infection (defined as patients who are not on anti-retroviral treatment and have detectable viral load and CD4+ \< 500/ml) * NOTE: HIV-positive patients who are well controlled on anti-retroviral therapy are allowed to enroll * History and/or current evidence of any of the following disorders: * Non-tumor related alteration of the calcium-phosphorus homeostasis that is considered clinically significant in the opinion of the Investigator * Ectopic mineralization/calcification, including but not limited to soft tissue, kidneys, intestine, or myocardia and lung, considered clinically significant in the opinion of the Investigator * Retinal or corneal disorder confirmed by retinal/corneal examination and considered clinically significant in the opinion of the Investigator * Uncontrolled intercurrent illness including, but not limited to: * Ongoing or active severe infection * NOTE: Must be afebrile \> 7 days to be eligible. Patient may be eligible if fever is present and infection has been ruled out or fever is related to tumor * Psychiatric illness/social situations that would limit compliance with study requirements * Clinically significant or uncontrolled cardiac disease, including unstable angina, acute myocardial infarction within 6 months from day 1 of study treatment administration, New York Heart Association class III and IV congestive heart failure, and uncontrolled arrhythmia * NOTE: Participants with pacemaker or with atrial fibrillation and well controlled heart rate are allowed * Other active malignancy \<6 months prior to pre-registration * EXCEPTIONS: Non-melanotic skin cancer, papillary thyroid cancer, or carcinoma-in-situ of the cervix, or others curatively treated and now considered to be at less than 30% risk of relapse are eligible * Prior organ transplantation