Study on Chemotherapy and Immunotherapy Followed by Radiation for Lung Cancer in Veterans

Inclusion Criteria

• Must be over 18 years old.
• Must have a good performance status, meaning able to carry out daily activities with little or no assistance.
• Must be eligible for treatment with both chemotherapy and radiation at the same time.
• Must have advanced lung cancer (Stage III NSCLC) that cannot be removed by surgery, as determined by a doctor or a team of specialists.
• Cancer must show a PD-L1 marker of 1% or higher.
• Must have cancer that can be measured using standard medical criteria.
• Must have good organ function based on medical tests.
• Must have available tumor tissue samples with enough cancer cells for analysis.

Exclusion Criteria

• Cannot have an active autoimmune disease that required treatment with immune-suppressing drugs in the past year.
• Cannot have uncontrolled immune system deficiencies, including HIV.
• Cannot be taking more than 10 mg of prednisone or equivalent steroids daily, except for supportive care.
• Cannot have tumors with specific genetic mutations (EGFR, ALK, ROS1, MET, or RET).
• Cannot have other serious health conditions that would prevent participation, as determined by a doctor.
• Cannot have had previous radiation or systemic treatment for advanced lung cancer.
• Cannot have psychiatric or substance abuse issues that would interfere with following the study requirements.
• Cannot be pregnant, breastfeeding, or planning to have children during the study and for 180 days after the last treatment.
• Cannot have a history of active tuberculosis.
• Cannot have active Hepatitis B or C.
• Cannot have received a live vaccine within 30 days before joining the study.
• Cannot have a diagnosis of Interstitial Lung Disease.
• Must be able to provide informed consent to participate in the study.