Study on Reduced Radiation and Standard Chemotherapy for HPV-Positive Throat Cancer

Inclusion Criteria

• Diagnosed with HPV-related squamous cell carcinoma of the throat (tonsil, base of tongue, or throat walls) through biopsy or surgery.
• Cancer of unknown origin in the neck is allowed if a lymph node biopsy is done.
• Must have visible cancer at the primary site or lymph nodes.
• No signs of cancer spread to distant parts of the body.
• Must have a CT or MRI scan of the neck.
• Performance status score of 0-2 or KPS score of 50 or higher.
• Age 18 or older (patients over 70 can enroll in a specific group).
• Adequate blood cell counts and organ function based on recent tests.
• Women of childbearing potential must have a negative pregnancy test.
• Must provide informed consent and be able to undergo MRI scans unless medically exempt.

Exclusion Criteria

• Previous radiation therapy to the head and neck.
• Having another primary cancer outside the throat area, unless approved by the study leaders.
• History of invasive cancer unless disease-free for 3 years or with a high cure rate.
• Previous chemotherapy for the throat cancer being studied (chemotherapy for other cancers is allowed).
• Severe active health issues, such as:
  • Recent unstable heart conditions or heart attack.
  • Active infections needing IV antibiotics.
  • Severe lung disease requiring hospitalization.
  • Liver problems causing jaundice or blood clotting issues.