Study on Shortened Radiation Therapy After TORS for HPV-Related Throat Cancer

Sponsor: Abramson Cancer Center at Penn Medicine

Sponsor score: 0
Inactive

ClinicalTrials ID:NCT05714657

Provider View

This clinical trial is testing if a reduced dose of radiation therapy is safe for patients with HPV-related throat cancer who have had surgery. The study also explores sparing the primary surgery area from radiation in certain patients.

Patient Parameters

Program Overview

This study is investigating whether a shorter course of radiation therapy is safe for patients with HPV-related oropharyngeal squamous cell carcinoma (a type of throat cancer) who have undergone surgery. The trial focuses on patients who have had a specific type of surgery called TORS and neck dissection. The goal is to see if reducing the radiation dose can still effectively control the cancer while minimizing side effects. The study will also look at the impact on quality of life and compare different radiation techniques.

Description

This trial is for patients with locally advanced HPV-related throat cancer who have had surgery to remove the cancer. The study will test if a shorter course of radiation therapy, possibly combined with chemotherapy, is as effective as the standard treatment. Patients will be monitored for cancer control in the treated area over two years. The study will also assess side effects, quality of life, and survival rates. Researchers will compare the effects of two types of radiation therapy: IMRT and proton therapy, to see which has fewer side effects and better quality of life outcomes.

Eligibility Criteria

Inclusion Criteria

  • Age 18 or older
  • Diagnosed with HPV-related oropharyngeal squamous cell carcinoma
  • Cancer stage T0 to T3 and N0 to N1, with no distant spread
  • Detectable HPV DNA in blood before surgery and undetectable after surgery
  • Good overall health with an ECOG performance status of 0 or 1

Exclusion Criteria

  • Previous radiation therapy to the head and neck
  • Cancer stage T4 or more than 5 positive lymph nodes
  • Cancer that has spread to distant parts of the body
  • Uncontrolled health conditions like heart failure or severe psychiatric illness that could interfere with the study

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