Study on Amivantamab for Treating Esophagogastric Cancer

Inclusion Criteria

• You or your legal representative must be willing to provide written consent to participate.
• You have esophagogastric cancer that has spread or cannot be removed by surgery and have already received at least one treatment.
• Your cancer must have specific genetic changes called EGFR or MET amplification, confirmed by specific tests.
• You have not previously received drugs targeting EGFR or MET for this type of cancer, unless you have developed new genetic changes after treatment.
• If your cancer is HER2 positive, it must have progressed after treatment with trastuzumab.
• You must have measurable cancer based on specific medical criteria.
• You are 18 years or older.
• You have a performance status score of 0, 1, or 2, indicating you are fully active or have some restrictions but can still do light work.
• Your organs are functioning well, as shown by specific blood tests.
• Women who can become pregnant and men with partners who can become pregnant must agree to use effective birth control methods.

Exclusion Criteria

• You have had chemotherapy or other cancer treatments within the last two weeks and have not recovered from side effects.
• You have had major surgery recently and have not fully recovered.
• You have another active cancer that needs treatment, except for certain skin or cervical cancers.
• You have active hepatitis B or C infections.
• You have other active or chronic liver diseases.
• You have uncontrolled health issues, such as poorly managed diabetes or ongoing infections.
• You have had blood clots in the lungs or deep veins within the last month.
• You have had a heart attack, stroke, or similar heart issues within the last six months.
• You have severe heart failure or have been hospitalized for heart failure recently.
• You have lung diseases that require ongoing treatment and have not resolved recently.
• You have unresolved skin rashes from previous cancer treatments.
• You have mental health or substance abuse issues that would interfere with the study.
• You are pregnant, breastfeeding, or planning to have children during the study and for six months after.
• You are a prisoner or are being held involuntarily.