Study on Targeted Radiation Therapy for People with Metastatic Non-Small Cell Lung Cancer (NSCLC)
Sponsor: Memorial Sloan Kettering Cancer Center
ClinicalTrials ID:NCT05657873
This clinical trial is exploring whether adding a specific type of radiation therapy to the liver, called liver stereotactic ablative radiotherapy (L-SABR), can improve treatment outcomes for people with metastatic non-small cell lung cancer (NSCLC) compared to standard drug therapy alone.
Patient Parameters
| Parameter | Options |
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Program Overview
The aim of this study is to determine if adding targeted radiation therapy to the liver, known as L-SABR, can enhance the effectiveness of standard drug treatments for people with metastatic non-small cell lung cancer (NSCLC). This study is for patients whose cancer has spread to the liver and who are receiving standard immunotherapy and possibly chemotherapy.
Eligibility Criteria
Inclusion Criteria
- Must be over 18 years old.
- Have a confirmed diagnosis of stage IV non-small cell lung cancer (NSCLC) without specific genetic mutations or rearrangements.
- Have newly diagnosed metastatic NSCLC with at least one liver metastasis.
- Plan to start standard immunotherapy, with or without chemotherapy, for at least three cycles. This can include combinations of different immunotherapy drugs.
- Have a performance status score of 0 to 2, indicating full activity or some restriction in strenuous activities.
- Have liver function within specified limits based on blood tests.
- Be eligible for the specific liver radiation therapy (L-SABR).
- If HIV positive, must be on effective treatment with a stable immune system.
Exclusion Criteria
- Have another cancer that could interfere with the study treatment.
- Have had previous radiation therapy to the liver.
- Have active Hepatitis B or C infections.
- Be on medications that suppress the immune system or have an active autoimmune disease.
- Be pregnant or breastfeeding.
- Not using effective birth control methods.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| BAPTIST ALLIANCE - MCI (Data Collection Only) | 33143 | Miami | Florida |
| Memorial Sloan Kettering at Basking Ridge (All Protocol Activities) | 07920 | Basking Ridge | New Jersey |
| Memorial Sloan Kettering Monmouth (All Protocol Activities) | 07748 | Middletown | New Jersey |
| Memorial Sloan Kettering Bergen (All protocol activities) | 07645 | Montvale | New Jersey |
| Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) | 11725 | Commack | New York |
| Memorial Sloan Kettering Westchester (All Protocol Activities) | 10604 | Harrison | New York |
| Memorial Sloan Kettering Cancer Center (All Protocol Activities) | 10065 | New York | New York |
| Memorial Sloan Kettering Nassau (All protocol activities) | 11553 | Rockville Centre | New York |
| Lehigh Valley Health Network (Data Collection Only) | 18103 | Allentown | Pennsylvania |
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