Study on Myeloablative Stem Cell Transplant with Donor for Blood Disorders

Inclusion Criteria

• Age 60 or younger.
• Good overall health with a performance status score of 70% or higher.
• Able to give written consent to participate.
• Adequate organ function, including:
  • Kidney function within normal limits or creatinine clearance of at least 40 ml/min.
  • Liver function with bilirubin, AST, and alkaline phosphatase less than 4 times the normal limit.
  • Lung function with oxygen diffusion capacity over 50% or oxygen saturation over 95% for children.
  • Heart function without severe heart failure or uncontrolled arrhythmia, and ejection fraction over 45%.
  • HIV infection with undetectable viral load and a management plan in place.
• Women and men of childbearing potential must use effective birth control during treatment.
• Must have a suitable donor for the transplant.
• Eligible blood disorders include:
  • Acute leukemias in remission or with specific risk factors.
  • Chronic myelogenous leukemia not responding to certain treatments.
  • Plasma cell leukemia after initial therapy.
  • Myeloproliferative neoplasms with intermediate or high risk.
  • Myelodysplastic syndromes with high risk features.
  • Chronic lymphocytic leukemia and other lymphomas with specific criteria.
  • Multiple myeloma with certain risk factors.
  • Other specific blood disorders as outlined in the study.

Exclusion Criteria

• Certain types of chemotherapy-resistant lymphomas.
• Chronic myelogenous leukemia in blast crisis.
• Lymphomas progressing on salvage therapy.
• Active cancer in the central nervous system.
• Recent myeloablative transplant in children or previous transplant in adults.
• Active or uncontrolled HIV infection.
• Active, uncontrolled infections.
• Pregnant or breastfeeding women, due to potential harm to the fetus.